- Clinical responses in seven out of 14 patients with synovial sarcoma by RECIST 1.1 -
- Clinical benefit in 13 out of 14 patients -
- One RECIST response maintained for more than 9 months after SPEAR T-cell infusion -
Out of the 14 patients with synovial sarcoma who have been treated in the expansion phase of this trial and have post-baseline scans, to date, seven have had clinical responses (including both confirmed and unconfirmed partial responses [PRs] by RECIST criteria) representing an overall response rate of 50%. Thirteen patients showed clinical benefit with best overall responses of PR (confirmed or unconfirmed; n=7) or stable disease (SD; n=6) – representing a disease control rate of 93%.
“This updated data set confirms that ADP-A2M4 continues to deliver clinical benefit, including RECIST responses, to patients with synovial sarcoma. It has also galvanized the support we have received from the sarcoma community, allowing us to rapidly open multiple sites and screen patients for the Phase 2 SPEARHEAD-1 trial,” said
“The responses in this trial so far are encouraging because the patients had previously been treated unsuccessfully with standard treatments,” said Dr.
Data presented today, which are updated since
Of the seven patients who have had best overall responses of confirmed or unconfirmed PRs, one patient has died, and six remain ongoing for follow up. Of these six patients, four have maintained a response for at least six months and one patient has maintained a response for more than nine months post-treatment.
Most adverse events were consistent with those typically experienced by cancer patients undergoing cytotoxic chemotherapy or other cancer immunotherapies.
Adaptimmune is a clinical-stage biopharmaceutical company focused on the development of novel cancer immunotherapy products for people with cancer. The Company’s unique SPEAR (Specific Peptide Enhanced Affinity Receptor) T‑cell platform enables the engineering of T-cells to target and destroy cancer across multiple solid tumors. For more information, please visit http://www.adaptimmune.com.
Adaptimmune Forward-Looking Statements
This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Quarterly Report on Form 10-Q filed with the
Sébastien Desprez – VP, Communications and Investor Relations
T: +44 1235 430 583
M: +44 7718 453 176
T: +1 215 825 9310
M: +1 215 460 8920
Source: Adaptimmune Therapeutics plc