“Professor Dyson is a luminary in the field of immune response regulation and, as such, is ideal to lead our expansion into autoimmune disease,” said
Adaptimmune’s goal is to restore the function of the immune system and inhibit the autoimmune response by delivering affinity enhanced Regulatory T-cells, called Tregs, to the site of the disease. Tregs are a subpopulation of immune cells that are involved in maintenance of self-tolerance in healthy individuals and are thought to suppress the action of potential autoreactive lymphocytes that would otherwise recognize and destroy normal tissue, causing autoimmune diseases.
Adaptimmune believes that by delivering affinity enhanced antigen-specific Tregs to the site of an autoimmune disease, it can inhibit the autoimmune response and restore self-tolerance within the immune system, thus reducing the impact of the disease. The company believes that this approach may provide a better tolerated approach with fewer side effects than currently approved therapeutic options. Adaptimmune is currently validating a number of initial targets that are expressed in high amounts only on tissues involved in certain autoimmune diseases; these can then be used to develop specific affinity enhanced T-cell therapies.
Adaptimmune is a clinical stage biopharmaceutical company focused on novel cancer immunotherapy products based on its T-cell receptor (TCR) platform. Established in 2008, the company aims to utilize the body’s own machinery – the T-cell – to target and destroy cancer cells by using engineered, increased affinity TCRs as a means of strengthening natural patient T-cell responses. Adaptimmune’s lead program is an affinity enhanced T-cell therapy targeting the NY-ESO cancer antigen. Its NY-ESO TCR affinity enhanced T-cell therapy has demonstrated signs of efficacy and tolerability in Phase 1/2 trials in solid tumors and in hematologic cancer types, including synovial sarcoma and multiple myeloma. In
This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Annual Report on Form 20-F filed with the
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