In a planned transition of responsibilities, Chairman, Dr.
Dr. Knowles has served as a Non-Executive Director of Adaptimmune since
Dr. Knowles has reshaped and led a transatlantic Board that now includes key players from the USA’s most prestigious biotechnology investment groups and pharmaceutical businesses, and members with specialist financial expertise. Milestone achievements for Adaptimmune during his tenure include: a strategic collaboration agreement with GlaxoSmithKline in 2014, expanded in
Adaptimmune currently has clinical trials ongoing in multiple indications including melanoma, multiple myeloma, non-small cell lung cancer, ovarian cancer and synovial sarcoma, as well as 12 wholly-owned research programs in development for multiple tumor types.
“It has been a privilege and a great pleasure to oversee Adaptimmune’s successful expansion,” commented Dr. Knowles. “The Company is now recognized as a clear leader in the immune-oncology space with a strong scientific and clinical track record in T-cell therapy driven by a focus on unmet patient need. It has been an incredible journey and I look forward to seeing Adaptimmune build further on its strong position.”
He added: “I am personally delighted that
“On behalf of the Board of Directors and management, I would like to express our appreciation for Jonathan Knowles’s instrumental contribution to the Company,” said
“We are fortunate, however, in having
“Adaptimmune is an exciting company with huge potential that has already made remarkable progress, thanks to the efforts of its experienced and highly committed staff,” commented Mr. Mott. “I am honored to become the Company’s next Chairman from 2017 and value the support of Jonathan, James and other Board and management team colleagues. I look forward to working with the team to rapidly progress the further development of Adaptimmune’s comprehensive pipeline of SPEAR T-cell therapies, which offer an opportunity to bring potentially breakthrough cancer treatments to patients.”
Adaptimmune is a clinical stage biopharmaceutical company focused on novel cancer immunotherapy products based on its SPEAR™ (Specific Peptide Enhanced Affinity Receptor) T-cell platform. Established in 2008, the company aims to utilize the body’s own machinery - the T-cell - to target and destroy cancer cells by using engineered, increased affinity TCRs as a means of strengthening natural patient T-cell responses. Adaptimmune’s lead program is a SPEAR T-cell therapy targeting the NY-ESO cancer antigen. Its NY-ESO SPEAR T-cell therapy has demonstrated signs of efficacy and tolerability in Phase 1/2 trials in solid tumors and in hematologic cancer types, including synovial sarcoma and multiple myeloma. Adaptimmune has a strategic collaboration and licensing agreement with GlaxoSmithKline for the development and commercialization of the NY-ESO TCR program. In addition, Adaptimmune has a number of proprietary programs. The company has identified over 30 intracellular target peptides preferentially expressed in cancer cells and is currently progressing 12 through unpartnered research programs. Adaptimmune has over 200 employees and is located in
This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Quarterly Report on Form 10-Q filed with the
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