This is the first collaborative study under the recently announced multi-year strategic alliance between Adaptimmune and The
"We are excited to initiate this triple tumor study with our partners at MD Anderson," said Dr.
This is a Phase I, open-label, modified 3+3 dose escalation study of autologous T-cells genetically engineered with an affinity optimized MAGE-A10 T-cell receptor in HLAA*0201 and HLA-A*0206 positive patients with inoperable or metastatic urothelial cancer (transitional cell cancer of the bladder, ureter or renal pelvis), melanoma, or squamous cell carcinoma of the head and neck expressing the MAGE-A10 antigen.
The study is part of a multi-center study intended to enroll up to 12 patients in leading clinical centers in
About Urothelial, Melanoma, or Head and Neck Tumors
Ninety percent of urothelial cancers originate in the bladder, while 8 percent originate in the renal pelvis and two percent in the ureter or urethra. Non-muscle invasive urothelial bladder cancer comprises 70 percent of newly diagnosed bladder cancers. The American Cancer Society’s estimates for bladder cancer in
Melanoma is a cancer that begins in specific skin cells called melanocytes. Because most of these cells still make melanin, melanoma tumors are often brown or black, though this is not always the case.
Squamous Cell Carcinoma of the Head and Neck
Cancers that are known collectively as head and neck cancers usually begin in the squamous cells that line the mucosal surfaces inside the head and neck (for example, inside the mouth, the nose, and the throat). These squamous cell cancers are often referred to as squamous cell carcinomas of the head and neck. There are two possible developmental paths for most head and neck cancers: environmental factors such as alcohol and tobacco, and HPV infection. Over the past 30 years, there has been a significant rise in the incidence of head and neck cancers caused by HPV. The majority of patients with head and neck cancer present with locally advanced disease. For those patients with stage III/IV locally advanced cancer, the prognosis is quite poor; 40 to 60 percent of patients relapse, and approximately 30 to 50 percent of patients live for 3 years after treatment with surgery and radiotherapy.
Adaptimmune is a clinical stage biopharmaceutical company focused on novel cancer immunotherapy products based on its SPEAR® (Specific Peptide Enhanced Affinity Receptor) T-cell platform. Established in 2008, the company aims to utilize the body’s own machinery - the T-cell - to target and destroy cancer cells by using engineered, increased affinity TCRs as a means of strengthening natural patient T-cell responses. Adaptimmune’s lead program is a SPEAR T-cell therapy targeting the NY-ESO cancer antigen. Its NY-ESO SPEAR T-cell therapy has demonstrated signs of efficacy and tolerability in Phase 1/2 trials in solid tumors and in hematologic cancer types, including synovial sarcoma and multiple myeloma. Adaptimmune has a strategic collaboration and licensing agreement with GlaxoSmithKline for the development and commercialization of the NY-ESO TCR program. In addition, Adaptimmune has a number of proprietary programs. These include SPEAR T-cell therapies targeting the MAGE-A10 and AFP cancer antigens, which both have open INDs, and a further SPEAR T-cell therapy targeting the MAGE-A4 cancer antigen that is in pre-clinical phase with IND acceptance targeted for 2017. The company has identified over 30 intracellular target peptides preferentially expressed in cancer cells and is currently progressing 12 through unpartnered research programs. Adaptimmune has over 250 employees and is located in
This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Quarterly Report on Form 10-Q filed with the
Adaptimmune Contacts Investor Relations
Will RobertsT: (215) 825-9306 E: firstname.lastname@example.org Juli Miller, Ph.D. T: (215) 825-9310 E: email@example.com Media Relations Margaret HenryT: +44 (0)1235 430036 Mobile: +44 (0)7710 304249 E: firstname.lastname@example.org